Angiotensin and angiotensin converting enzyme tissue levels in two-kidney, one clip hypertensive rats.

Angiotensin and angiotensin converting enzyme tissue levels in two-kidney, one clip hypertensive rats.

Renal tissue angiotensin I (Ang I) and II (Ang II) content and angiotensin converting enzyme activity were assessed in both kidneys during initial (7 days) and maintenance (25 days) phases of two-kidney, one clip hypertension in rats. At 7 and 25 days, systolic arterial pressure was 146 +/- 2 and 170 +/- 7 mm Hg, respectively. After 7 days, Ang I content of clipped kidneys was 64% and 70% highe...

Increased angiotensin-converting enzyme activity of aorta in two-kidney, one-clip Goldblatt hypertension in rats.

There is increasing evidence that conversion of angiotensin I into angiotensin I1 can occur in the renal vasculature of humans [l l , and in the vascular beds of the hind limb of the dog 121. In previous experiments the specific angiotensionconverting enzyme in rat aorta [31 has been demonstrated. More recently, Mizuno et al. [41 have studied the subcellular localization of the enzyme activity ...

Angiotensin Converting Enzyme in Sarcoidosis

Effects of angiotensin inhibition and renal denervation in two-kidney, one clip hypertensive rats.

Neural and angiotensin-mediated influences that alter hemodynamic and excretory behavior of the nonclipped kidney of two-kidney, one clip hypertensive rats were assessed by sequential acute surgical denervation of the nonclipped kidney and intravenous infusion of converting enzyme inhibitor (SQ 20881), 3 mg/kg X hr. Normal and two-kidney, one clip hypertensive rats (0.2-mm silver clip on the ri...

Vascular renin-angiotensin system in two-kidney, one clip hypertensive rats.

The possible role of the renin-angiotensin system in the maintenance of hypertension in two-kidney, one clip hypertensive rats was studied. Plasma renin activity rose rapidly and markedly in association with the elevation of blood pressure and then decreased gradually, although blood pressure remained high. Renin activity in the lung, aorta, and mesenteric artery also increased with the develop...